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Tweetie for Mac is a fully featured Twitter client for the Mac OS. An iPhone version is also available.
Tweetie is available in two versions. An ad-supported free version, and a reasonably priced ad-free version.
Beak claims to be an innovative Twitter client for the Mac OS. It is scheduled for public release in April 2009.
Buzzbird is an open source Twitter client for the Mac OS X. The application is in Beta with a comprehensive set of features planned.
Bluebird is a Twitter client for the Mac OS X platform.
Bluebird supports some innovative concepts like XHTML/CSS Skinning. It includes a comprehensive set of features that includes Public Timeline View, Direct Messages, Multi Account Support, Skins/Themes, etc. The application is still in Beta.
multiTwit is a simple Adobe AIR based application that allows you to send tweets to multiple twitter accounts from your desktop.
Given below is a video explaining the app:
Spreadtweet is an Adobe AIR based Twitter application that looks a lot like a spreadsheet. The aim is for users at work to be able to ‘fool their bosses’ into believing that they are working hard crunching numbers on Excel
Bitter a social networking tool that allows you to post to and get messages from Twitter, Plurk, Pownce and Friend Feed.
Seesmic, the developers of the popular Twhirl application, has a new Adobe-AIR based application called Seesmic Desktop.
Nambu is a Twitter and FriendFeed client for the Mac OS X and is also available for the iPhone and iPod. On Mac OS X, it runs as a native application and adds several features like threaded conversations, different views, filters, etc.