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blu

blu is a Twitter desktop client for Windows Vista and Windows 7.

TwitBabble

TwitBabble is an Adobe AIR based desktop Twitter client.

TwiPing

TwiPing is a Windows Desktop application that allows you to do mass follow/unfollow based on keywords.

twitcher

Twitcher is an easy to use twitter client powered by Adobe Air that runs on your Mac or Windows desktop.

Catfood Follower

Catfood Follower is a desktop Twitter tool for following new friends that follow you and removing friends that don’t follow you back. Catfood Follower supports Windows XP and Vista.

Tweetie for Mac is a fully featured Twitter client for the Mac OS. An iPhone version is also available. Tweetie is available in two versions. An ad-supported free version, and a reasonably priced ad-free version.

Beak

Beak claims to be an innovative Twitter client for the Mac OS. It is scheduled for public release in April 2009.

Buzzbird

Buzzbird is an open source Twitter client for the Mac OS X. The application is in Beta with a comprehensive set of features planned.

Bluebird

Bluebird is a Twitter client for the Mac OS X platform. Bluebird supports some innovative concepts like XHTML/CSS Skinning. It includes a comprehensive set of features that includes Public Timeline View, Direct Messages, Multi Account Support, Skins/Themes, etc. The application is still in Beta.

multiTwit

multiTwit is a simple Adobe AIR based application that allows you to send tweets to multiple twitter accounts from your desktop. Given below is a video explaining the app:

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