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Penolo lets you easily create fun sketches and share them with your followers on Twitter. You also get the option to add to someones sketch!
Scribbr is an application that allows you to create ‘freehand’ drawings that you can post to Twitter along with a description. It uses OAuth to login so you don’t need to provide your Twitter password to the app. Scribbr works on Firefox, Safari and Chrome.
Glyph let’s you draw on Twitter. You can also reply to your friends’ tweets with a drawing and even draw over your friends’ Glyphs using retweet.
DrawTweet is an Adobe AIR based desktop application that enables you to share your creations quickly with a slick and simple UI that is aimed at making drawing a social experience. It is distributed through the Bamboo Dock platform, enabling Wacom pen-tablet users to take advantage of pressure sensitivity.
TwitDraw allows you to draw graffiti and post it to Twitter! It provides a very basic canvas and brush with which you can draw.