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Spaz is an open-source Twitter client. Spaz is written using Adobe Air and will run on all Air compatible platforms like Mac, Linux, and Windows. Download Spaz.
Deskbar is a Gnome widget you can embed in a panel and can be used for opening applications, opening items from your browser history, doing web searches and all sorts. Twitter Deskbar enables you to post updates from this deskbar.
gtwitter is a GTK+ based application for Linux. GUI is inspired by Mac client Twitterrific.
ZenTwitter is a small script that allows you to update your Twitter status without the need of having a browser window open all the time. Download ZenTwitter.
Twitter for Vim allows you to update your Twitter status, check public timeline or your friends timeline all right from within your Vim. It requires your Vim to be compiled with Python bindings (which is, in most distributions by default). Download Twitter for Vim.