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Catfood Follower is a desktop Twitter tool for following new friends that follow you and removing friends that don’t follow you back. Catfood Follower supports Windows XP and Vista.
Spreadtweet is an Adobe AIR based Twitter application that looks a lot like a spreadsheet. The aim is for users at work to be able to ‘fool their bosses’ into believing that they are working hard crunching numbers on Excel
Bitter a social networking tool that allows you to post to and get messages from Twitter, Plurk, Pownce and Friend Feed.
Seesmic, the developers of the popular Twhirl application, has a new Adobe-AIR based application called Seesmic Desktop.
Sideline is an Adobe AIR desktop application built with the Yahoo! User Interface Library (YUI). It allows users to create and group custom queries by topics of interest. Sideline is an open source application released under the BSD license.
sobees is a desktop application for online social networks. sobees offers an easy unified user experience to get, organize and share information from the likes of Twitter, Facebook, Friendfeed, Digg, Flickr and Youtube directly on the desktop.
TwitterLocal is an Adobe-AIR based client that shows you location-based Twitter feeds from the public timeline.
Live Tweeter is a Songbird extension allow you to post what you are listening on Twitter, MSN/Windows Live Messenger, Pidgin, Mercury, IRC and more. Songbird is an open-source customizable music player that’s under active development.
Found.im is a software platform for letting your friends, family, and coworkers know where you are and what you’re doing or thinking. It is a website, a desktop application, a Facebook application, Myspace application; and it has plugins for twitter and RSS.
TweetEasy is a Windows Desktop Client for Twitter. It has a small footprint, occupying only 2.5MB. It attaches itself to the Windows taskbar and allows you to post updates to Twitter.