TweetTabs
TweetTabs is an amazing Twitter search application that makes you feel as if you’re using a Desktop application rather than accessing a website.
You can specify your own search terms or search on the trending topics. Search results auto-refresh and you have options to reply, retweet, etc.
All-in-all a very simple to use application that has a very good UI design. TweetTabs was launched by TweetMeme.

Via Mashable, TechCrunch
Traffic rankings are sourced from multiple sources, if available, for the Twitter application. This includes Alexa, and Compete rankings.
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